Complete remission of advanced and recurrent cervical cancer with pembrolizumab treatment- 3 case reports

Complete remission of advanced and recurrent cervical cancer with pembrolizumab treatment- 3 case reports

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Objective: Recurrent cervical cancer Statues is hard to treat when occurring in a previous radiated area and unresectable or distant metastasis.We present three such cases who achieved complete remission (CR) after chemoradiotherapy and pembrolizumab.Case Report: Case 1 was diagnosed with cervical adenocarcinoma, stage IVB.She obtained CR after concurrent chemoradiotherapy (CCRT) and post-CCRT adjuvant chemotherapy and bevacizumab.Recurrence at previous irradiated sacral bone was controlled with pembrolizumab and CCRT using proton therapy (PT).

Case 2 was diagnosed with stage IVB squamous cell carcinoma.First recurrence occurred at inguinal lymph node (LN).Secondary recurrence occurred at paraaortic LN ten years later.PT with chemotherapy and pembrolizumab achieved CR.Case 3 had a small cell carcinoma (stage IVB) with bone metastasis.

She had CR to CCRT with etoposide-cisplatin.Liver metastasis was salvaged with CCRT and pembrolizumab.Conclusion: CCRT with pembrolizumab is potentially curative for recurrent cervical cancer conventionally Heatshrink Tubing Pack amenable for palliation.